OriDB Curated Paper

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Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae.

Weihong Xu, Jennifer G Aparicio, Oscar M Aparicio, Simon Tavaré

BMC Genomics (2006), 7(0):276Data to DownloadPubMed | PubMed Central | BMC Genomics

Eukaryotic replication origins exhibit different initiation efficiencies and activation times within S-phase. Although local chromatin structure and function influences origin activity, the exact mechanisms remain poorly understood. A key to understanding the exact features of chromatin that impinge on replication origin function is to define the precise locations of the DNA sequences that control origin function. In S. cerevisiae, Autonomously Replicating Sequences (ARSs) contain a consensus sequence (ACS) that binds the Origin Recognition Complex (ORC) and is essential for origin function. However, an ACS is not sufficient for origin function and the majority of ACS matches do not function as ORC binding sites, complicating the specific identification of these sites.

OriDB annotation of this paper:

ARS assay

ARS102, ARS102.5, ARS105, ARS108, ARS111, ARS112, ARS201, ARS203, ARS206, ARS212, ARS213, ARS215.5, ARS217, ARS218, ARS219, ARS221, ARS221.5, ARS223, ARS227, ARS229, ARS404, ARS1007.5, ARS1017.5, ARS103, ARS107.5, ARS113, ARS200, ARS207.8, ARS210.5, ARS219.5, ARS222.5, ARS228.5, ARS400, ARS402.5, ARS405.5, ARS413.5, ARS426.5, ARS427.5, ARS429.5, ARS430.5, ARS603.1, ARS608.5, ARS1009.5, ARS1018.5

2D gel

None curated.

ChIP of replication origin proteins

ARS102, ARS102.5, ARS103, ARS at I-10, ARS104, ARS105, ARS106, ARS107, ARS107.5, ARS108, ARS109, ARS110, ARS111, ARS112, ARS113, ARS200, ARS201, ARS201.5, ARS202, ARS203, ARS206, ARS207, ARS207.1, ARS207.5, ARS207.8, ARS208, ARS209, ARS at II-279, ARS210.5, ARS211, ARS212, ARS213, ARS214, ARS215, ARS215.5, ARS at II-479, ARS216, ARS217, ARS218, ARS219, ARS219.5, ARS220, ARS221, ARS221.5, ARS222, ARS222.5, ARS223, ARS224, ARS225, ARS227, ARS228, ARS228.5, ARS229, ARS at II-812, ARS300, ARS at III-5, ARS301, ARS302, ARS303, ARS320, ARS302, ARS304, ARS305, ARS306, ARS307, ARS308, ARS309, ARS at III-138, ARS at III-163, ARS310, ARS313, ARS314, ARS at III-200, ARS at III-224, ARS315, ARS316, ARS318, ARS319, ARS400, ARS at IV-9, ARS403, ARS402.5, ARS404, ARS405, ARS405.5, ARS406, ARS407, ARS408, ARS409, ARS at IV-220, ARS409.5, ARS410, ARS412, ARS413, ARS413.5, ARS414, ARS415, ARS at IV-444, ARS416, ARS at IV-477, ARS417, ARS417.5, ARS418, ARS419, ARS420, ARS421, ARS422, ARS at IV-721, ARS422.5, ARS423, ARS425, ARS426.5, ARS at IV-899, ARS427.5, ARS428, ARS429, ARS429.5, ARS430, ARS430.5, ARS431, ARS431.5, ARS432, ARS432.5, ARS433, ARS434, ARS at IV-1275, ARS435, ARS437, ARS at IV-1380, ARS440, ARS441, ARS442, ARS446, ARS447, ARS at IV-1499, ARS at IV-1524, ARS at IV-1531, ARS at V-1, ARS503, ARS504.2, ARS at V-18, ARS507, ARS at V-68, ARS508, ARS at V-110, ARS510, ARS511, ARS at V-184, ARS512, ARS at V-256, ARS513.5, ARS513.7, ARS514, ARS514.5, ARS at V-317, ARS516, ARS517, ARS518, ARS519, ARS520, ARS521, ARS522, ARS523, ARS at V-576, ARS at VI-1, ARS600.1, ARS600.2, ARS600.3, ARS600.4, ARS601, ARS602, ARS at VI-53, ARS603, ARS603.1, ARS603.5, ARS604, ARS605, ARS606, ARS607, ARS608, ARS608.5, ARS609, ARS610, ARS at VI-269, ARS at VII-0, ARS at VII-8, ARS700.5, ARS at VII-33, ARS702, ARS704, ARS at VII-115, ARS706, ARS707, ARS at VII-171, ARS709, ARS710, ARS712, ARS at VII-275, ARS714, ARS716, ARS717, ARS718, ARS at VII-481, ARS719, ARS720, ARS at VII-553, ARS721, ARS722, ARS at VII-576, ARS724.5, ARS at VII-621, ARS726, ARS727, ARS728, ARS729, ARS731, ARS at VII-847, ARS at VII-883, ARS731.5, ARS732, ARS733, ARS734, ARS735, ARS at VII-1005, ARS735.5, ARS at VII-1074, ARS131a, ARS at VII-1090, ARS at VIII-1, ARS131n, ARS802, ARS804, ARS at VIII-58, ARS805, ARS at VIII-88, ARS805.7, ARS at VIII-116, ARS at VIII-135, ARS809, ARS810, ARS at VIII-215, ARS813, ARS815, ARS816, ARS at VIII-381, ARS818, ARS820, ARS at VIII-452, ARS821, ARS822, ARS at VIII-505, ARS823, ARS823.5, ARS at VIII-551, ARS824, ARS at VIII-553, ARS at VIII-562, ARS at IX-1, ARS at IX-8, ARS at IX-17, ARS at IX-31, ARS905, ARS907, ARS908, ARS909, ARS911, ARS911.5, ARS912, ARS at IX-190, ARS913, ARS at IX-226, ARS at IX-238, ARS913.5, ARS914, ARS at IX-249, ARS916, ARS at IX-308, ARS at IX-323, ARS919, ARS920, ARS at IX-407, ARS922, ARS922.5, ARS at IX-439, ARS1001, ARS1002, ARS1003, ARS1004, ARS1005, ARS1006, ARS1007, ARS at X-121, ARS1007.5, ARS1008, ARS at X-212, ARS1009, ARS1009.5, ARS1010, ARS1011, ARS at X-355, ARS1012, ARS1013, ARS1014, ARS1015, ARS1016, ARS1017, ARS1017.5, ARS1018, ARS1018.5, ARS1019, ARS at X-644, ARS1020, ARS1021, ARS at X-702, ARS1022, ARS1023, ARS1024, ARS1025, ARS at XI-1, ARS at XI-8, ARS1103, ARS1104.5, ARS at XI-114, ARS1106, ARS at XI-164, ARS1106.3, ARS1106.5, ARS1106.7, ARS at XI-236, ARS1107, ARS1107.5, ARS at XI-327, ARS1109, ARS at XI-344, ARS1112, ARS1113, ARS1114, ARS1114.5, ARS at XI-463, ARS1116, ARS at XI-520, ARS1117, ARS1118, ARS1120, ARS at XI-633, ARS1123, ARS at XI-662, ARS at XII-1, ARS at XII-7, ARS at XII-12, ARS at XII-31, ARS1203, ARS1205, ARS1206, ARS1206.5, ARS at XII-140, ARS1209, ARS at XII-199, ARS1210, ARS1211, ARS1211.5, ARS1212, ARS1212.5, ARS1213, ARS1215, ARS1216, ARS1216.5, ARS at XII-461, ARS at XII-468, ARS at XII-494, ARS1217, ARS at XII-599, ARS1218, ARS at XII-607, ARS1219, ARS at XII-618, ARS at XII-638, ARS1219.7, ARS1220, ARS1222, ARS1223, ARS at XII-786, ARS1226, ARS at XII-806, ARS1227, ARS at XII-839, ARS1227.5, ARS1229, ARS1231, ARS1233, ARS at XII-1020, ARS1234, ARS at XII-1043, ARS1235, ARS at XII-1056, ARS at XII-1064, ARS at XII-1071, ARS at XII-1078, ARS at XIII-1, ARS at XIII-6, ARS at XIII-25, ARS1303, ARS1304, ARS at XIII-45, ARS1304.7, ARS1305, ARS1307, ARS1307.5, ARS at XIII-227, ARS1309, ARS at XIII-269, ARS1310, ARS at XIII-340, ARS at XIII-342, ARS1312, ARS at XIII-373, ARS at XIII-417, ARS1315, ARS1316, ARS at XIII-482, ARS1319, ARS1320, ARS1322, ARS at XIII-569, ARS1323, ARS1324, ARS1325, ARS1326, ARS1327, ARS1328, ARS1329, ARS1330, ARS at XIII-837, ARS1331.5, ARS1331.7, ARS1332, ARS at XIII-919, ARS at XIII-923, ARS at XIV-1, ARS at XIV-9, ARS at XIV-15, ARS1405, ARS at XIV-36, ARS1406, ARS1407, ARS1410, ARS1411, ARS1412, ARS1413, ARS at XIV-253, ARS1414, ARS1415, ARS at XIV-344, ARS1417, ARS1419, ARS1420, ARS1421, ARS1422, ARS at XIV-556, ARS1424, ARS1426, ARS1427, ARS at XIV-705, ARS1428, ARS1428.5, ARS1429, ARS at XIV-783, ARS at XV-1, ARS at XV-11, ARS at XV-19, ARS at XV-24, ARS1506.5, ARS1507, ARS1508, ARS at XV-104, ARS1509, ARS1509.5, ARS at XV-160, ARS1510, ARS1511, ARS1512, ARS at XV-332, ARS1513, ARS at XV-348, ARS at XV-354, ARS at XV-372, ARS at XV-398, ARS at XV-445, ARS at XV-459, ARS at XV-464, ARS1514, ARS1515.5, ARS1515.7, ARS1516, ARS at XV-577, ARS1517, ARS at XV-605, ARS at XV-618, ARS1519, ARS at XV-663, ARS1520, ARS1521, ARS at XV-763, ARS1523, ARS1524, ARS1525, ARS1526, ARS at XV-900, ARS at XV-902, ARS1528, ARS1529, ARS at XV-999, ARS at XV-1020, ARS at XV-1023, ARS1529.5, ARS at XV-1058, ARS at XV-1072, ARS at XV-1081, ARS at XV-1091, ARS at XVI-1, ARS1601, ARS1602, ARS at XVI-19, ARS1604, ARS1605, ARS at XVI-91, ARS1607, ARS at XVI-163, ARS at XVI-179, ARS at XVI-191, ARS at XVI-196, ARS1609, ARS at XVI-242, ARS at XVI-262, ARS at XVI-274, ARS1614, ARS at XVI-299, ARS at XVI-304, ARS at XVI-318, ARS1617, ARS at XVI-369, ARS at XVI-377, ARS1618, ARS1619, ARS at XVI-428, ARS at XVI-440, ARS at XVI-454, ARS1620.5, ARS at XVI-500, ARS1621, ARS at XVI-553, ARS at XVI-560, ARS1622, ARS1622.5, ARS at XVI-569, ARS1622.7, ARS at XVI-589, ARS1623, ARS1624, ARS at XVI-691, ARS1625, ARS at XVI-701, ARS at XVI-729, ARS1626, ARS1626.5, ARS1627, ARS at XVI-824, ARS1628, ARS at XVI-864, ARS at XVI-873, ARS1630, ARS1631, ARS at XVI-930, ARS at XVI-942, ARS at XVI-947

Replication timing

None curated.

Replication in hydroxyurea

None curated.

Predicted origins

None curated.

Confirmed sequence element

ARS1020, ARS1019, ARS1018, ARS1015, ARS1014, ARS1011, ARS1009, ARS1007.5, ARS1007, ARS1005, ARS1004, ARS1003, ARS1002, ARS1001

Predicted sequence element

ARS102, ARS102.5, ARS104, ARS105, ARS106, ARS108, ARS109, ARS109, ARS110, ARS111, ARS111, ARS112, ARS200, ARS201, ARS202, ARS206, ARS207, ARS208, ARS209, ARS209, ARS211, ARS212, ARS216, ARS216, ARS217, ARS218, ARS219, ARS219, ARS219.5, ARS220, ARS220, ARS221, ARS221, ARS221.5, ARS222, ARS222.5, ARS224, ARS227, ARS229, ARS229, ARS at II-812, ARS300, ARS301, ARS302, ARS303, ARS320, ARS304, ARS305, ARS306, ARS307, ARS308, ARS309, ARS309, ARS at III-146, ARS310, ARS310, ARS310, ARS310, ARS313, ARS314, ARS315, ARS316, ARS319, ARS400, ARS at IV-9, ARS403, ARS403, ARS402.5, ARS404, ARS405.5, ARS406, ARS409, ARS409, ARS409.5, ARS412, ARS413, ARS413.5, ARS415, ARS at IV-444, ARS at IV-444, ARS416, ARS417, ARS417.5, ARS417.5, ARS418, ARS419, ARS419, ARS420, ARS421, ARS421, ARS422, ARS422.5, ARS422.5, ARS423, ARS425, ARS426.5, ARS at IV-899, ARS428, ARS429, ARS430, ARS430.5, ARS431, ARS431.5, ARS432.5, ARS433, ARS435, ARS at IV-1380, ARS440, ARS441, ARS442, ARS446, ARS447, ARS447, ARS at IV-1524, ARS at V-1, ARS504.2, ARS507, ARS508, ARS508, ARS510, ARS511, ARS at V-184, ARS512, ARS at V-256, ARS513.5, ARS513.7, ARS514, ARS514.5, ARS514.5, ARS514.5, ARS at V-317, ARS516, ARS518, ARS519, ARS520, ARS520, ARS521, ARS522, ARS522, ARS523, ARS at V-576, ARS600.1, ARS600.2, ARS600.4, ARS601, ARS602, ARS601, ARS602, ARS603, ARS603, ARS603.1, ARS604, ARS605, ARS606, ARS607, ARS608, ARS609, ARS610, ARS at VII-0, ARS at VII-8, ARS at VII-33, ARS702, ARS704, ARS704, ARS at VII-115, ARS706, ARS709, ARS710, ARS712, ARS714, ARS716, ARS718, ARS719, ARS719, ARS721, ARS722, ARS726, ARS727, ARS728, ARS731.5, ARS731.5, ARS733, ARS734, ARS734, ARS735, ARS735.5, ARS735.5, ARS at VII-1074, ARS131a, ARS at VII-1090, ARS at VIII-1, ARS131n, ARS802, ARS804, ARS805, ARS810, ARS at VIII-215, ARS813, ARS at VIII-381, ARS818, ARS820, ARS822, ARS823, ARS823.5, ARS at VIII-551, ARS824, ARS at VIII-562, ARS at IX-1, ARS at IX-8, ARS at IX-17, ARS905, ARS908, ARS909, ARS911, ARS911.5, ARS912, ARS913, ARS at IX-226, ARS913.5, ARS914, ARS916, ARS919, ARS920, ARS920, ARS922, ARS at IX-439, ARS1001, ARS1002, ARS1003, ARS1004, ARS1004, ARS1005, ARS1005, ARS1006, ARS1006, ARS1006, ARS1006, ARS1007, ARS1007, ARS1007.5, ARS at X-212, ARS at X-212, ARS1009.5, ARS1015, ARS1018.5, ARS1019, ARS at X-644, ARS1021, ARS1023, ARS1023, ARS at XI-1, ARS1103, ARS1104.5, ARS1104.5, ARS1106.3, ARS1106.7, ARS at XI-236, ARS1107.5, ARS1109, ARS1112, ARS1112, ARS1114, ARS1114.5, ARS at XI-463, ARS1116, ARS1118, ARS1120, ARS at XI-633, ARS1123, ARS at XI-662, ARS at XI-662, ARS at XII-1, ARS at XII-7, ARS at XII-12, ARS1203, ARS1206, ARS1206, ARS at XII-140, ARS1209, ARS at XII-199, ARS1211, ARS1211.5, ARS1211.5, ARS1213, ARS1215, ARS1216, ARS1216, ARS1216.5, ARS1216.5, ARS at XII-468, ARS at XII-468, ARS at XII-468, ARS1217, ARS1218, ARS at XII-607, ARS1219, ARS1220, ARS1223, ARS at XII-786, ARS1226, ARS1227.5, ARS1229, ARS1233, ARS1233, ARS at XII-1043, ARS at XII-1043, ARS1235, ARS at XII-1064, ARS at XII-1071, ARS at XII-1071, ARS at XII-1078, ARS at XIII-1, ARS at XIII-6, ARS1304, ARS at XIII-45, ARS1305, ARS1307, ARS1307.5, ARS1310, ARS at XIII-340, ARS at XIII-342, ARS1312, ARS1316, ARS1320, ARS at XIII-569, ARS1323, ARS1325, ARS1327, ARS1329, ARS1330, ARS at XIII-837, ARS1331.5, ARS1331.7, ARS at XIII-923, ARS at XIV-1, ARS at XIV-9, ARS at XIV-9, ARS at XIV-15, ARS1405, ARS1406, ARS1407, ARS1410, ARS1411, ARS1412, ARS1413, ARS1414, ARS1415, ARS at XIV-344, ARS at XIV-344, ARS1419, ARS1421, ARS1421, ARS1422, ARS1422, ARS1424, ARS1426, ARS1426, ARS1427, ARS1429, ARS at XIV-783, ARS at XV-1, ARS at XV-11, ARS at XV-19, ARS1506.5, ARS1507, ARS1508, ARS1509, ARS1509, ARS1509.5, ARS1510, ARS1512, ARS at XV-332, ARS1513, ARS at XV-348, ARS at XV-459, ARS at XV-464, ARS1514, ARS1515.7, ARS at XV-618, ARS at XV-663, ARS1520, ARS1521, ARS1521, ARS1523, ARS1524, ARS at XV-900, ARS1528, ARS1529.5, ARS at XV-1058, ARS at XV-1072, ARS at XV-1081, ARS at XV-1081, ARS at XV-1081, ARS at XV-1091, ARS at XVI-1, ARS1601, ARS1601, ARS at XVI-19, ARS1604, ARS1605, ARS1607, ARS1614, ARS at XVI-299, ARS at XVI-299, ARS1617, ARS at XVI-377, ARS1618, ARS1619, ARS1620.5, ARS1621, ARS1622, ARS1622, ARS1622.7, ARS1624, ARS at XVI-729, ARS at XVI-729, ARS1626, ARS1626.5, ARS1627, ARS1628, ARS1628, ARS at XVI-864, ARS1630, ARS1630, ARS at XVI-930, ARS1631, ARS at XVI-942, ARS at XVI-947

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