Likely ARS at IV-899

No systematic name assigned

Other names: proARS427

Status: Likely ARS: Identified by 5 genome-wide studies.

Genomic Location: Chr4:898253-899887
Probably within convergent intergenic space between YDR216W and YDR217C.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -156.8 ΔG° (kcal/mol) at location 898663.

Time of Origin Replication (Trep): This site was not identified as an origin by any curated timing study (Raghuraman et al. (2001); Yabuki et al. (2002); Alvino et al. (2007)), suggesting that this site is not chromosomally active for replication initiation.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at IV-899 has unique ID: 133

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ARS at IV-899 has unique ID: 133

Studies that cloned this origin

None curated.


Studies that analyzed this origin by 2D gel

None curated.


Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr4:899042-899587

Xu et al. (2006): Chr4:898255-899885

Szilard et al. (2010): Chr4:899245-899255

Szilard et al. (2010): Chr4:898705-898715


Studies that measured the replication time of this origin

The replication time of origin has not be reported by any curated study.


Studies that measured the activity of this origin in hydroxyurea (HU)

Crabbé et al. (2010): Chr4:898253-899887 (Activity detected in: wild-type, rev3 rad30, ctf4, ddc1, rad24, pol2-12, elg1, tof1, mrc1-AQ, mrc1-AQ rad9, ctf8, ctf18, mrc1, dcc1, mec1-100, rad53, mec1)


Studies that predicted the location of this origin

This origin has not been predicted by any curated study.



ARS at IV-899 has unique ID: 133

Studies that confirmed an essential ACS element

None curated.


Studies that predicted an essential ACS element

  Xu et al. (2006):      CACCATTTTTATGTTTTGATGAATGATTTTCCCC  
ACS LOGO:   ACS_logo  

ARS at IV-899 has unique ID: 133

Alignments from the UCSC genome browser

No phylogenetic sequence conservation data.

ARS at IV-899 has unique ID: 133

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at IV-899 has unique ID: 133

Genome-wide studies that identified this origin

Wyrick et al. (2001): PubMed | Science

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.


Studies that cloned this origin

None identified.


Studies that analyzed this origin by 2D gel

None identified.


Studies that confirmed an essential ACS element

None identified.


Studies that predicted an essential ACS element

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics


ARS at IV-899 has unique ID: 133