Dubious ARS at XII-31

No systematic name assigned

Other names: proARS1202

Status: Dubious ARS: Identified by 9 genome-wide studies.

Genomic Location: Chr12:28749-32505
Resolution insufficient to assign intergenic space.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -161.8 ΔG° (kcal/mol) at location 29609.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 34.4 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XII-31 has unique ID: 395

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ARS at XII-31 has unique ID: 395

Studies that cloned this origin

None curated.


Studies that analyzed this origin by 2D gel

None curated.


Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr12:30209-31384

Xu et al. (2006): Chr12:28751-32503

Shor et al. (2009): Chr12:30700-32300 (orc2-1/wt peak ratio: 0.40)

Szilard et al. (2010): Chr12:31875-31885

Müller et al. (2010): Chr12:30950-32300 (orc1-bah-delta/wt peak ratio: 0.54)


Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr12:31764 (Trep: 34.4 min.) (Confidence: 9)

Alvino et al. (2007): Chr12:29286 (Peak first observed at 12.5 min.)


Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr12:31666 (Activity detected in: rad53)

Crabbé et al. (2010): Chr12:31292-31792 (Activity detected in: ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)


Studies that predicted the location of this origin

This origin has not been predicted by any curated study.



ARS at XII-31 has unique ID: 395

Studies that confirmed an essential ACS element

None curated.


Studies that predicted an essential ACS element

  Eaton et al. (2010):      AATATTGATGTTTTGTTGTGTAAATGTTCTATC   
ACS LOGO:   ACS_logo  

ARS at XII-31 has unique ID: 395

Alignments from the UCSC genome browser

No phylogenetic sequence conservation data.

ARS at XII-31 has unique ID: 395

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at XII-31 has unique ID: 395

Genome-wide studies that identified this origin

Raghuraman et al. (2001): PubMed | Science

Wyrick et al. (2001): PubMed | Science

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Alvino et al. (2007): PubMed | PubMed Central | Mol. Cell. Biol.

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.


Studies that cloned this origin

None identified.


Studies that analyzed this origin by 2D gel

None identified.


Studies that confirmed an essential ACS element

None identified.


Studies that predicted an essential ACS element

Eaton et al. (2010): PubMed | PubMed Central | Genes Dev.


ARS at XII-31 has unique ID: 395