Dubious ARS at XI-327

No systematic name assigned

Status: Dubious ARS: Identified by 6 genome-wide studies.

Genomic Location: Chr11:326153-327067
Within gene: YKL060C.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: No elements have been reported for this origin.

Helical Stability: Minimum -159.4 ΔG° (kcal/mol) at location 326413.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 25.5 min.
Yabuki et al. (2002) — Trep: 21.6 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XI-327 has unique ID: 718

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ARS at XI-327 has unique ID: 718

Studies that cloned this origin

None curated.


Studies that analyzed this origin by 2D gel

None curated.


Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Xu et al. (2006): Chr11:326155-327065

Shor et al. (2009): Chr11:326000-327100 (orc2-1/wt peak ratio: 1.21)


Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr11:325415 (Trep: 25.5 min.) (Confidence: 8)

Yabuki et al. (2002): Chr11:329002 (Trep: 21.6 min.)

Alvino et al. (2007): Chr11:329440 (Peak first observed at 12.5 min.)


Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr11:329000 (Activity detected in: wild-type, rad53)


Studies that predicted the location of this origin

This origin has not been predicted by any curated study.



ARS at XI-327 has unique ID: 718

Studies that confirmed an essential ACS element

None curated.


Studies that predicted an essential ACS element

None curated.

ACS LOGO:   ACS_logo  


ARS at XI-327 has unique ID: 718

Alignments from the UCSC genome browser

No phylogenetic sequence conservation data.

ARS at XI-327 has unique ID: 718

These notes are manually curated. To submit notes for this replication origin site please contact us.

Friday, 4th December 2009 - Conrad Nieduszynski:

Status manually changed to 'Dubious'. Shor et al. (2009) report that there is no detectable ARS activity in this region.

ARS at XI-327 has unique ID: 718

Genome-wide studies that identified this origin

Raghuraman et al. (2001): PubMed | Science

Yabuki et al. (2002): PubMed

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Alvino et al. (2007): PubMed | PubMed Central | Mol. Cell. Biol.

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.


Studies that cloned this origin

None identified.


Studies that analyzed this origin by 2D gel

None identified.


Studies that confirmed an essential ACS element

None identified.


Studies that predicted an essential ACS element

None identified.


ARS at XI-327 has unique ID: 718