No systematic name assigned

Status: Dubious ARS: Identified by 4 genome-wide studies.

Genomic Location: Chr12:466233-468907
Probably within divergent intergenic space between RDN18-2 and RDN5-2.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence: View sequence

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -168.9 ΔG° (kcal/mol) at location 466433.

Time of Origin Replication (Trep): This site was not identified as an origin by any curated timing study (Raghuraman et al. (2001); Yabuki et al. (2002); Alvino et al. (2007)), suggesting that this site is not chromosomally active for replication initiation.

Origin activity in HU: Origin activity not detected in HU.

ARS at XII-468 has unique ID: 723

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ARS at XII-468 has unique ID: 723

Studies that cloned this origin

None curated.

Studies that analyzed this origin by 2D gel

None curated.

Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Xu et al. (2006): Chr12:466235-468905

Shor et al. (2009): Chr12:449900-469200 (orc2-1/wt peak ratio: 0.67)

Szilard et al. (2010): Chr12:468045-468055

Müller et al. (2010): Chr12:467600-469025 (orc1-bah-delta/wt peak ratio: 0.25)

Studies that measured the replication time of this origin

The replication time of origin has not be reported by any curated study.

Studies that measured the activity of this origin in hydroxyurea (HU)

This origin has not be reported as active in HU by any curated study.

Studies that predicted the location of this origin

This origin has not been predicted by any curated study.

ARS at XII-468 has unique ID: 723

Studies that confirmed an essential ACS element

None curated.

Studies that predicted an essential ACS element

Xu et al. (2006):

A

T

T

G

T

T

T

A

T

G

T

T

T

T

G

T

G

T

G

A

T

G

A

T

T

T

T

A

C

A

T

T

T

T

Xu et al. (2006):

A

T

T

T

T

G

T

A

T

G

T

T

T

T

G

T

A

T

G

T

T

C

C

C

G

C

G

C

G

T

T

T

C

C

Xu et al. (2006):

C

T

A

T

T

C

T

A

T

G

T

T

T

T

C

T

T

A

C

T

C

C

T

A

T

G

T

C

T

A

T

T

C

A

ACS LOGO:

ARS at XII-468 has unique ID: 723

Alignments from the UCSC genome browser

ARS at XII-468 has unique ID: 723

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at XII-468 has unique ID: 723

Genome-wide studies that identified this origin

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Studies that cloned this origin

None identified.

Studies that analyzed this origin by 2D gel

None identified.

Studies that confirmed an essential ACS element

None identified.

Studies that predicted an essential ACS element

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

ARS at XII-468 has unique ID: 723