ARS1411

Status: Confirmed ARS: Confirmed by ARS assay and 2D gel and identified by 9 genome-wide studies.

Genomic Location: Chr14:169566-169804
Within divergent intergenic space between YNL254C and YNL253W.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence: View sequence

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -147.2 ΔG° (kcal/mol) at location 169716.

Time of Origin Replication (Trep): Yabuki et al. (2002) — Trep: 30.4 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XIV-170 has unique ID: 510

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ARS at XIV-170 has unique ID: 510

Studies that cloned this origin

Nieduszynski et al. (2006): Chr14:169566-169804

Studies that analyzed this origin by 2D gel

Friedman et al. (1996): Chr14:168204-172042

Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr14:169247-170017

Xu et al. (2006): Chr14:168995-170915

Shor et al. (2009): Chr14:169400-170200 (orc2-1/wt peak ratio: 0.23)

Szilard et al. (2010): Chr14:169825-169835

Müller et al. (2010): Chr14:169325-170225 (orc1-bah-delta/wt peak ratio: 0.74)

Studies that measured the replication time of this origin

Yabuki et al. (2002): Chr14:167469 (Trep: 30.4 min.)

Alvino et al. (2007): Chr14:170140 (Peak first observed at 12.5 min.)

Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr14:169666 (Activity detected in: rad53)

Crabbé et al. (2010): Chr14:169566-169804 (Activity detected in: ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)

Studies that predicted the location of this origin

This origin has not been predicted by any curated study.

ARS at XIV-170 has unique ID: 510

Studies that confirmed an essential ACS element

None curated.

Studies that predicted an essential ACS element

Nieduszynski et al. (2006):

A

A

T

T

T

A

A

C

G

T

T

T

T

G

T

T

Xu et al. (2006):

T

A

A

T

T

T

A

A

C

G

T

T

T

T

G

T

T

T

C

T

T

C

C

G

T

C

A

T

C

A

T

A

T

C

Eaton et al. (2010):

T

A

A

T

T

T

A

A

C

G

T

T

T

T

G

T

T

T

C

T

T

C

C

G

T

C

A

T

C

A

T

A

T

ACS LOGO:

ARS at XIV-170 has unique ID: 510

Alignments from the UCSC genome browser

ARS at XIV-170 has unique ID: 510

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at XIV-170 has unique ID: 510

Genome-wide studies that identified this origin

Wyrick et al. (2001): PubMed | Science

Yabuki et al. (2002): PubMed

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Alvino et al. (2007): PubMed | PubMed Central | Mol. Cell. Biol.

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.

Studies that cloned this origin

Nieduszynski et al. (2006): PubMed | PubMed Central | Genes Dev.

Studies that analyzed this origin by 2D gel

Friedman et al. (1996): PubMed

Studies that confirmed an essential ACS element

None identified.

Studies that predicted an essential ACS element

Nieduszynski et al. (2006): PubMed | PubMed Central | Genes Dev.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Eaton et al. (2010): PubMed | PubMed Central | Genes Dev.

ARS at XIV-170 has unique ID: 510