OriDB - ARS at XII-599

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Status: Dubious ARS: Identified by 11 genome-wide studies.

Genomic Location: Chr12:595804-602804
Resolution insufficient to assign intergenic space.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: No elements have been reported for this origin.

Helical Stability: Minimum -159.6 ΔG° (kcal/mol) at location 602794.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 20.2 min.
Yabuki et al. (2002) — Trep: 17.8 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XII-599 has unique ID: 419

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ARS at XII-599 has unique ID: 419

Studies that cloned this origin

None curated.

Studies that analyzed this origin by 2D gel

None curated.

Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr12:602463-603337

Xu et al. (2006): Chr12:602205-603825

Shor et al. (2009): Chr12:602700-603800 (orc2-1/wt peak ratio: 0.64)

Szilard et al. (2010): Chr12:603105-603115

Müller et al. (2010): Chr12:602825-603650 (orc1-bah-delta/wt peak ratio: 0.16)

Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr12:606519

Raghuraman et al. (2001): Chr12:592012 (Trep: 20.2 min.) (Confidence: 6)

Yabuki et al. (2002): Chr12:599304 (Trep: 17.8 min.)

Alvino et al. (2007): Chr12:596890 (Peak first observed at 12.5 min.)

Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr12:604000 (Activity detected in: wild-type, rad53)

Crabbé et al. (2010): Chr12:602938-603155 (Activity detected in: wild-type, rad9, rev3 rad30, eco1, ctf4, ddc1, rad24, pol2-12, elg1, tof1, mrc1-AQ, mrc1-AQ rad9, ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)