Status: Confirmed ARS: Confirmed by ARS assay and identified by 10 genome-wide studies.
Genomic Location:
Chr12:659823-660072
Within tandem intergenic space between YLR257W and YLR258W.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser
DNA Sequence:
Origin Sequence Elements: ACS predicted.
Helical Stability: Minimum -160.2 ΔG° (kcal/mol) at location 660023.
Time of Origin Replication (Trep):
Raghuraman et al. (2001) — Trep: 28.5 min.
Yabuki et al. (2002) — Trep: 20.5 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.
Origin activity in HU: Origin activity detected in HU — more details.
ARS at XII-660 has unique ID: 425
ARS at XII-660 has unique ID: 425
Chr12:659823-660072
None curated.
Chr12:659791-660716
Chr12:658995-660785
Chr12:659200-660400 (orc2-1/wt peak ratio: 0.61)
Chr12:660165-660175
Chr12:659075-660650 (orc1-bah-delta/wt peak ratio: 0.54)
Chr12:662043 (Trep: 28.5 min.) (Confidence: 9)
Chr12:656804 (Trep: 20.5 min.)
Chr12:658330 (Peak first observed at 12.5 min.)
Chr12:659250 (Activity detected in: wild-type, rad53)
Chr12:659823-660072 (Activity detected in: wild-type, rad9, rev3 rad30, eco1, ctf4, ddc1, rad24, pol2-12, elg1, tof1, mrc1-AQ, mrc1-AQ rad9, ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)
This origin has not been predicted by any curated study.
ARS at XII-660 has unique ID: 425
| Nieduszynski et al. (2006): | G | C | T | T | T | T | T | A | T | G | T | T | T | A | T | T | ||||||||||||||||||||||||||
| Xu et al. (2006): | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | C | A | T | G | G | A | T | T | A | C | G | A | A | A | T | T | T | G | C | ||||||||
| Eaton et al. (2010): | G | C | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | C | A | T | G | G | A | T | T | A | C | G | A | A | A | T | T | |||||||||
| ACS LOGO: |  | |||||||||||||||||||||||||||||||||||||||||
ARS at XII-660 has unique ID: 425
| Predicted ACS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S. cerevisiae | A | A | A | A | T | T | T | C | T | G | T | C | A | A | G | T | A | A | T | G | G | C | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | C | A | T | G | G | A | T | T | A | C | G | A | A | A | T | T | T | G | C |
| S. kudriavzevii | T | G | A | A | T | T | T | C | G | - | T | T | A | A | A | T | C | G | T | A | G | G | T | T | T | T | T | A | C | G | T | T | T | A | T | T | T | T | G | A | A | A | T | T | C | C | T | T | G | T | T | T | T | T | C | C |
| S. mikatae | G | A | A | G | T | T | T | T | T | - | T | A | A | G | C | T | A | A | T | G | A | C | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | C | T | A | A | A | A | T | T | A | C | C | G | G | - | - | T | T | A | C |
| S. paradoxus | A | A | A | A | T | T | T | T | G | - | T | C | A | A | G | C | A | G | T | - | G | C | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | T | T | T | A | G | A | T | T | A | T | G | A | T | T | T | A | T | G | C |
| S. bayanus | G | A | A | A | A | C | T | C | G | - | T | T | A | A | A | G | A | A | C | G | G | T | T | T | T | T | T | A | T | G | T | T | T | A | T | T | T | C | T | A | A | A | A | - | - | A | G | C | A | C | C | C | C | T | C | C |
| : | * | : | : | : | * | : | * | * | : | : | : | : | * | * | * | * | * | * | : | * | * | * | * | * | * | * | * | : | : | : | : | : | : | : | * | * | ||||||||||||||||||||
ARS at XII-660 has unique ID: 425
These notes are manually curated. To submit notes for this replication origin site please contact us.
There are no notes entered for this replication origin site.
ARS at XII-660 has unique ID: 425
PubMed | PubMed Central | Nat. Cell Biol.
PubMed | PubMed Central | BMC Genomics
PubMed | PubMed Central | Mol. Cell. Biol.
PubMed | PubMed Central | PLoS Genet.
PubMed | PubMed Central | Nat. Struct. Mol. Biol.
PubMed | PubMed Central | Genes Dev.
PubMed | Nat. Struct. Mol. Biol.
PubMed | PubMed Central | Genes Dev.
None identified.
None identified.
PubMed | PubMed Central | Genes Dev.
PubMed | PubMed Central | BMC Genomics
PubMed | PubMed Central | Genes Dev.
ARS at XII-660 has unique ID: 425
