Likely ARS at IV-1380

No systematic name assigned

Other names: proARS439

Status: Likely ARS: Identified by 8 genome-wide studies.

Genomic Location: Chr4:1379198-1380752
Probably within convergent intergenic space between YDR457W and YDR458C.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -154.9 ΔG° (kcal/mol) at location 1379268.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 31.5 min.
Yabuki et al. (2002) — Trep: 28.8 min.
Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at IV-1380 has unique ID: 154

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ARS at IV-1380 has unique ID: 154

Studies that cloned this origin

None curated.


Studies that analyzed this origin by 2D gel

None curated.


Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr4:1379630-1380089

Xu et al. (2006): Chr4:1379200-1380750

Szilard et al. (2010): Chr4:1379755-1379765


Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr4:1380110 (Trep: 31.5 min.) (Confidence: 9)

Yabuki et al. (2002): Chr4:1384791 (Trep: 28.8 min.)

Alvino et al. (2007): Chr4:1377000 (Peak first observed at 12.5 min.)


Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr4:1381500 (Activity detected in: rad53)

Crabbé et al. (2010): Chr4:1379198-1380752 (Activity detected in: ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)


Studies that predicted the location of this origin

This origin has not been predicted by any curated study.



ARS at IV-1380 has unique ID: 154

Studies that confirmed an essential ACS element

None curated.


Studies that predicted an essential ACS element

  Xu et al. (2006):      TACTTTTCTTTGTTTTGTTTTCGTATTTGAGTTT  
ACS LOGO:   ACS_logo  

ARS at IV-1380 has unique ID: 154

Alignments from the UCSC genome browser

No phylogenetic sequence conservation data.

ARS at IV-1380 has unique ID: 154

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at IV-1380 has unique ID: 154

Genome-wide studies that identified this origin

Raghuraman et al. (2001): PubMed | Science

Wyrick et al. (2001): PubMed | Science

Yabuki et al. (2002): PubMed

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Alvino et al. (2007): PubMed | PubMed Central | Mol. Cell. Biol.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.


Studies that cloned this origin

None identified.


Studies that analyzed this origin by 2D gel

None identified.


Studies that confirmed an essential ACS element

None identified.


Studies that predicted an essential ACS element

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics


ARS at IV-1380 has unique ID: 154