OriDB Curated Paper

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Replication in hydroxyurea: it's a matter of time.

Gina M Alvino, David Collingwood, John M Murphy, Jeffrey Delrow, Bonita J Brewer, M K Raghuraman

Mol. Cell. Biol. (2007), 27(18):6396-406Data to DownloadPubMed | PubMed Central | Mol. Cell. Biol.

Hydroxyurea (HU) is a DNA replication inhibitor that negatively affects both the elongation and initiation phases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast has shown that, during a short exposure to HU, MEC1/RAD53 prevent initiation at some late S phase origins. In this study, we have performed microarray experiments to follow the fate of all origins over an extended exposure to HU. We show that the genome-wide progression of DNA synthesis, including origin activation, follows the same pattern in the presence of HU as in its absence, although the time frames are very different. We find no evidence for a specific effect that excludes initiation from late origins. Rather, HU causes S phase to proceed in slow motion; all temporal classes of origins are affected, but the order in which they become active is maintained. We propose a revised model for the checkpoint response to HU that accounts for the continued but slowed pace of the temporal program of origin activation.

OriDB annotation of this paper:

ARS assay

None curated.

2D gel

None curated.

ChIP of replication origin proteins

None curated.

Replication timing

ARS at I-17, ARS105, ARS106, ARS at I-166, ARS at I-206, ARS111, ARS201.5, ARS201.7, ARS202, ARS at II-72, ARS203, ARS at II-96, ARS at II-100, ARS206, ARS207, ARS207.5, ARS at II-229, ARS208, ARS at II-246, ARS at II-293, ARS at II-309, ARS at II-301, ARS211, ARS212, ARS213, ARS214, ARS216, ARS217, ARS at II-549, ARS219, ARS at II-584, ARS220, ARS at II-627, ARS at II-695, ARS222, ARS222.5, ARS at II-732, ARS224, ARS227, ARS228, ARS228.5, ARS305, ARS306, ARS307, ARS308, ARS309, ARS at III-146, ARS at III-138, ARS at III-163, ARS310, ARS at III-224, ARS315, ARS316, ARS404, ARS at IV-51, ARS405, ARS at IV-96, ARS406, ARS at IV-170, ARS409, ARS at IV-220, ARS410, ARS at IV-257, ARS413, ARS414, ARS415, ARS at IV-444, ARS416, ARS at IV-477, ARS417, ARS417.5, ARS418, ARS420, ARS421, ARS422, ARS at IV-739, ARS422.5, ARS423, ARS425, ARS at IV-820, ARS at IV-879, ARS428, ARS429, ARS at IV-975, ARS430, ARS at IV-1022, ARS431, ARS431.5, ARS432, ARS432.5, ARS at IV-1205, ARS433, ARS434, ARS at IV-1275, ARS435, ARS at IV-1306, ARS at IV-1308, ARS437, ARS at IV-1356, ARS at IV-1380, ARS440, ARS at IV-1455, ARS442, ARS447, ARS at IV-1506, ARS at IV-1499, ARS503, ARS504, ARS504.2, ARS at V-18, ARS507, ARS508, ARS510, ARS511, ARS at V-165, ARS512, ARS514, ARS513.7, ARS at V-317, ARS516, ARS517, ARS518, ARS519, ARS520, ARS at V-510, ARS522, ARS600.3, ARS600.4, ARS603, ARS at VI-62, ARS at VI-99, ARS603.1, ARS603.5, ARS604, ARS606, ARS607, ARS700.5, ARS at VII-26, ARS702, ARS at VII-70, ARS704, ARS at VII-115, ARS706, ARS707, ARS at VII-167, ARS710, ARS714, ARS at VII-288, ARS at VII-319, ARS at VII-338, ARS716, ARS717, ARS718, ARS719, ARS at VII-481, ARS720, ARS at VII-540, ARS721, ARS722, ARS at VII-576, ARS at VII-582, ARS726, ARS727, ARS728, ARS729, ARS731, ARS731.5, ARS at VII-883, ARS732, ARS733, ARS at VII-970, ARS734, ARS735, ARS at VII-1005, ARS735.5, ARS805, ARS at VIII-58, ARS at VIII-88, ARS805.5, ARS at VIII-116, ARS805.7, ARS807, ARS at VIII-135, ARS809, ARS813, ARS815, ARS816, ARS at VIII-367, ARS818, ARS820, ARS at VIII-452, ARS821, ARS822, ARS at VIII-505, ARS905, ARS at IX-31, ARS907, ARS908, ARS909, ARS at IX-114, ARS911, ARS912, ARS at IX-183, ARS at IX-205, ARS913, ARS at IX-220, ARS at IX-238, ARS913.5, ARS914, ARS at IX-249, ARS916, ARS at IX-314, ARS at IX-308, ARS919, ARS920, ARS at IX-363, ARS922, ARS at IX-407, ARS1004, ARS1005, ARS1007, ARS at X-121, ARS at X-139, ARS1007.5, ARS at X-171, ARS1008, ARS at X-212, ARS1009, ARS1010, ARS at X-305, ARS1011, ARS1012, ARS1013, ARS1014, ARS1016, ARS1017, ARS at X-475, ARS1018, ARS1019, ARS1018.5, ARS1020, ARS1021, ARS1022, ARS at X-719, ARS at XI-16, ARS at XI-24, ARS1103, ARS1104.5, ARS1105.5, ARS1106, ARS1106.3, ARS1106.7, ARS1107, ARS1107.5, ARS1109, ARS at XI-334, ARS at XI-327, ARS at XI-382, ARS1112, ARS1113, ARS1114, ARS1114.5, ARS1113.5, ARS1116, ARS at XI-520, ARS1118, ARS at XI-584, ARS1120, ARS at XI-617, ARS at XI-633, ARS1123, ARS at XII-31, ARS1206, ARS1206.5, ARS at XII-140, ARS1208, ARS1209, ARS1211, ARS1212, ARS at XII-296, ARS1212.5, ARS1213, ARS1215, ARS at XII-419, ARS1216, ARS1217, ARS at XII-599, ARS1218, ARS1219, ARS at XII-618, ARS1220, ARS1220.5, ARS1223, ARS at XII-749, ARS1226, ARS at XII-786, ARS1227, ARS1227.5, ARS1229, ARS at XII-931, ARS1231, ARS at XII-977, ARS1232, ARS1233, ARS at XII-1020, ARS1234, ARS1303, ARS1304, ARS1305, ARS1307, ARS1308, ARS at XIII-203, ARS at XIII-227, ARS1309, ARS at XIII-269, ARS1310, ARS at XIII-290, ARS1312, ARS at XIII-373, ARS1315, ARS1316, ARS1319, ARS1320, ARS at XIII-543, ARS at XIII-574, ARS at XIII-569, ARS1323, ARS1325, ARS1326, ARS1327, ARS at XIII-763, ARS1330, ARS1332, ARS1405, ARS at XIV-36, ARS1406, ARS1407, ARS at XIV-95, ARS at XIV-96, ARS at XIV-85, ARS at XIV-116, ARS1410, ARS at XIV-159, ARS1411, ARS at XIV-180, ARS at XIV-180, ARS1412, ARS1413, ARS at XIV-253, ARS1414, ARS1415, ARS at XIV-325, ARS1311.7, ARS at XIV-358, ARS at XIV-359, ARS1417, ARS at XIV-416, ARS1419, ARS at XIV-459, ARS1420, ARS1422, ARS at XIV-556, ARS1424, ARS at XIV-617, ARS1426, ARS1427, ARS1428, ARS at XIV-705, ARS1428.5, ARS at XIV-731, ARS at XIV-734, ARS1506.5, ARS at XV-45, ARS1507, ARS1508, ARS at XV-79, ARS1509, ARS1510, ARS at XV-160, ARS1510.5, ARS1511, ARS1512, ARS1513, ARS at XV-332, ARS1513.5, ARS at XV-464, ARS1514, ARS at XV-495, ARS1515.5, ARS1516, ARS1517, ARS at XV-605, ARS1519, ARS at XV-663, ARS1520, ARS at XV-705, ARS1521, ARS at XV-737, ARS at XV-763, ARS1523, ARS1524, ARS1525, ARS at XV-848, ARS1526, ARS at XV-902, ARS1528, ARS1529, ARS at XV-1012, ARS at XV-1020, ARS1529.5, ARS at XV-1058, ARS1604, ARS at XVI-57, ARS1605, ARS at XVI-91, ARS1607, ARS at XVI-163, ARS at XVI-191, ARS at XVI-196, ARS1609, ARS at XVI-215, ARS at XVI-262, ARS at XVI-266, ARS1614, ARS at XVI-318, ARS at XVI-324, ARS1618, ARS at XVI-377, ARS1619, ARS at XVI-423, ARS1618.5, ARS1620.5, ARS at XVI-454, ARS1621, ARS at XVI-553, ARS at XVI-560, ARS1622, ARS1622.5, ARS1622.7, ARS at XVI-589, ARS1623, ARS1624, ARS at XVI-691, ARS1625, ARS1626.5, ARS1627, ARS at XVI-824, ARS1628, ARS at XVI-851, ARS at XVI-873, ARS1630

Replication in hydroxyurea

None curated.

Predicted origins

None curated.

Confirmed sequence element

None curated.

Predicted sequence element

None curated.

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