No systematic name assigned

Status: Dubious ARS: Identified by 5 genome-wide studies.

Genomic Location: Chr3:192527-193643
Probably within divergent intergenic space between YCR035C and YCR036W.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence: View sequence

Origin Sequence Elements: No elements have been reported for this origin.

Helical Stability: Minimum -155.7 ΔG° (kcal/mol) at location 193347.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 16.9 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at III-193 has unique ID: 79

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ARS at III-193 has unique ID: 79

Studies that cloned this origin

None curated.

Studies that analyzed this origin by 2D gel

Poloumienko et al. (2001): Chr3:192312-195908

Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr3:193027-193143

Shor et al. (2009): Chr3:193800-195900 (orc2-1/wt peak ratio: 0.50)

Müller et al. (2010): Chr3:193775-195125 (orc1-bah-delta/wt peak ratio: 0.82)

Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr3:200020 (Trep: 16.9 min.) (Confidence: 9)

Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr3:195000 (Activity detected in: rad53)

Studies that predicted the location of this origin

This origin has not been predicted by any curated study.

ARS at III-193 has unique ID: 79

Studies that confirmed an essential ACS element

None curated.

Studies that predicted an essential ACS element

None curated.

ACS LOGO:

ARS at III-193 has unique ID: 79

Alignments from the UCSC genome browser

ARS at III-193 has unique ID: 79

These notes are manually curated. To submit notes for this replication origin site please contact us.

Friday, 18th August 2006 - Conrad Nieduszynski:

Status manually changed to 'Dubious'. Carol Newlon's lab report that there is no detectable ARS activity in this region. [Thanks to Carol Newlon for this information.]

ARS at III-193 has unique ID: 79

Genome-wide studies that identified this origin

Raghuraman et al. (2001): PubMed | Science

Wyrick et al. (2001): PubMed | Science

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Studies that cloned this origin

None identified.

Studies that analyzed this origin by 2D gel

Poloumienko et al. (2001): PubMed | PubMed Central

Studies that confirmed an essential ACS element

None identified.

Studies that predicted an essential ACS element

None identified.

ARS at III-193 has unique ID: 79