Confirmed ARS at XV-73

ARS1507

Other names: proARS1507

Status: Confirmed ARS: Confirmed by ARS assay and identified by 8 genome-wide studies.

Genomic Location: Chr15:72636-72872
Within tandem intergenic space between YOL132W and YOL131W.
View at UCSC genome browser
View on SGD Chromosome Features Map
View at SGD gbrowser site
View at Ensembl browser

DNA Sequence:

Origin Sequence Elements: ACS predicted.

Helical Stability: Minimum -150.1 ΔG° (kcal/mol) at location 72846.

Time of Origin Replication (Trep): Alvino et al. (2007) — Peak first observed at 12.5 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XV-73 has unique ID: ARS1507

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ARS at XV-73 has unique ID: ARS1507

Studies that cloned this origin

Nieduszynski et al. (2006): Chr15:72636-72872


Studies that analyzed this origin by 2D gel

None curated.


Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr15:72714-73030

Xu et al. (2006): Chr15:71353-73558

Shor et al. (2009): Chr15:72000-73500 (orc2-1/wt peak ratio: 0.49)

Szilard et al. (2010): Chr15:72675-72685

Müller et al. (2010): Chr15:71975-73625 (orc1-bah-delta/wt peak ratio: 0.40)


Studies that measured the replication time of this origin

Alvino et al. (2007): Chr15:79000 (Peak first observed at 12.5 min.)


Studies that measured the activity of this origin in hydroxyurea (HU)

Feng et al. (2006): Chr15:73000 (Activity detected in: rad53)

Crabbé et al. (2010): Chr15:72636-72872 (Activity detected in: ddc1, rad24, pol2-12, elg1, tof1, mrc1-AQ, mrc1-AQ rad9, ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)


Studies that predicted the location of this origin

This origin has not been predicted by any curated study.



ARS at XV-73 has unique ID: ARS1507

Studies that confirmed an essential ACS element

None curated.


Studies that predicted an essential ACS element

  Nieduszynski et al. (2006):       TTTTTTACTTTTAGTT                   
  Xu et al. (2006):      TTTTTTTACTTTTAGTTTATTTTTTTAGACTTTA  
  Eaton et al. (2010):      TTTTTTTACTTTTAGTTTATTTTTTTAGACTTT   
ACS LOGO:   ACS_logo  

ARS at XV-73 has unique ID: ARS1507

Alignments from the UCSC genome browser

Predicted ACS
S. cerevisiaeCTCTTGGGTTGTGTTTGCTTTTTTTTACTTTTAGTTTATTTTTTTAGACTTTAATG
S. kudriavzeviiCTCTTGGGTTGTTTCTGTTCTTTTATACTTTGAATATAATATTCTAGGTTT--ATG
S. mikataeCTCTTGGATGGTTTTTGCTTTTTTATACTTTGAATACTATCTTTTAAAT----ATG
S. paradoxusCGCTTGGGTTGTTTTTGCTTTTTTTTACTTTAAGTATATATTATTAGGC----ATG
S. bayanusCCCCCGGTTTGTTCTTGCTCTTTTATATTTTAAGTATATGTCATCACGTTCC-AAA
**::***:**:::**:*******:***:**::::::*::*::

ARS at XV-73 has unique ID: ARS1507

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at XV-73 has unique ID: ARS1507

Genome-wide studies that identified this origin

Wyrick et al. (2001): PubMed | Science

Feng et al. (2006): PubMed | PubMed Central | Nat. Cell Biol.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Alvino et al. (2007): PubMed | PubMed Central | Mol. Cell. Biol.

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.


Studies that cloned this origin

Nieduszynski et al. (2006): PubMed | PubMed Central | Genes Dev.


Studies that analyzed this origin by 2D gel

None identified.


Studies that confirmed an essential ACS element

None identified.


Studies that predicted an essential ACS element

Nieduszynski et al. (2006): PubMed | PubMed Central | Genes Dev.

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Eaton et al. (2010): PubMed | PubMed Central | Genes Dev.


ARS at XV-73 has unique ID: ARS1507