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Simon R V Knott, Christopher J Viggiani, Oscar M Aparicio, Simon Tavaré
BMC Bioinformatics (2009), 10(0):305PubMed | PubMed Central | BMC Bioinformatics
Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been employed to examine features such as protein binding and histone modifications on a genome-wide scale in a variety of cell types. Array data from the latter studies typically have a high proportion of enriched probes whose signals vary considerably (due to heterogeneity in the cell population), and this makes their normalization and downstream analysis difficult.
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