OriDB Curated Paper

Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.

Kenji Shimada, Yukako Oma, Thomas Schleker, Kazuto Kugou, Kunihiro Ohta, Masahiko Harata, Susan M Gasser

Curr. Biol. (2008), 18(8):566-75PubMed | Curr. Biol.

Chromatin remodeling complexes facilitate the access of enzymes that mediate transcription, replication or repair of DNA by modulating nucleosome position and/or composition. Ino80 is the DNA-dependent Snf2-like ATPase subunit of a complex whose nucleosome remodeling activity requires actin-related proteins, Arp4, Arp5 and Arp8, as well as two RuvB-like DNA helicase subunits. Budding yeast mutants deficient for Ino80 function are not only hypersensitive to reagents that induce DNA double-strand breaks, but also to those that impair replication fork progression.

OriDB annotation of this paper:

ARS assay

None curated.

2D gel

None curated.

ChIP of replication origin proteins

None curated.

Replication timing

None curated.

Replication in hydroxyurea

None curated.

Predicted origins

None curated.

Confirmed sequence element

None curated.

Predicted sequence element

None curated.