ARS1210

Status: Confirmed ARS: Confirmed by ARS assay and identified by 7 genome-wide studies.

Genomic Location: Chr12:222410-222792
Within tandem intergenic space between YLR036C and YLR037C.
• View at UCSC genome browser
• View on SGD Chromosome Features Map
• View at SGD gbrowser site
• View at Ensembl browser

DNA Sequence: View sequence

Origin Sequence Elements: No elements have been reported for this origin.

Helical Stability: Minimum -158.3 ΔG° (kcal/mol) at location 222670.

Time of Origin Replication (Trep): Raghuraman et al. (2001) — Trep: 18.9 min.

Origin activity in HU: Origin activity detected in HU — more details.

ARS at XII-223 has unique ID: 404

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ARS at XII-223 has unique ID: 404

Studies that cloned this origin

Liachko et al. (2010): Chr12:222410-222792

Studies that analyzed this origin by 2D gel

None curated.

Studies that detected this origin by chromatin immunoprecipitation (ChIP)

Wyrick et al. (2001): Chr12:222133-222686

Xu et al. (2006): Chr12:221985-223285

Shor et al. (2009): Chr12:222300-223100 (orc2-1/wt peak ratio: 0.63)

Szilard et al. (2010): Chr12:222485-222495

Müller et al. (2010): Chr12:222275-222875 (orc1-bah-delta/wt peak ratio: 0.51)

Studies that measured the replication time of this origin

Raghuraman et al. (2001): Chr12:227350 (Trep: 18.9 min.) (Confidence: 9)

Studies that measured the activity of this origin in hydroxyurea (HU)

Crabbé et al. (2010): Chr12:222378-222878 (Activity detected in: eco1, ctf4, pol2-12, elg1, tof1, mrc1-AQ, mrc1-AQ rad9, ctf8, ctf18, mrc1, dcc1, ctf18 rad9, mec1-100, rad53, mec1)

Studies that predicted the location of this origin

This origin has not been predicted by any curated study.

ARS at XII-223 has unique ID: 404

Studies that confirmed an essential ACS element

None curated.

Studies that predicted an essential ACS element

None curated.

ACS LOGO:

ARS at XII-223 has unique ID: 404

Alignments from the UCSC genome browser

ARS at XII-223 has unique ID: 404

These notes are manually curated. To submit notes for this replication origin site please contact us.

There are no notes entered for this replication origin site.

ARS at XII-223 has unique ID: 404

Genome-wide studies that identified this origin

Raghuraman et al. (2001): PubMed | Science

Wyrick et al. (2001): PubMed | Science

Xu et al. (2006): PubMed | PubMed Central | BMC Genomics

Shor et al. (2009): PubMed | PubMed Central | PLoS Genet.

Szilard et al. (2010): PubMed | PubMed Central | Nat. Struct. Mol. Biol.

Müller et al. (2010): PubMed | PubMed Central | Genes Dev.

Crabbé et al. (2010): PubMed | Nat. Struct. Mol. Biol.

Studies that cloned this origin

Liachko et al. (2010): PubMed | PubMed Central | PLoS Genet.

Studies that analyzed this origin by 2D gel

None identified.

Studies that confirmed an essential ACS element

None identified.

Studies that predicted an essential ACS element

None identified.

ARS at XII-223 has unique ID: 404